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Article: Caffeine-induced [Ca2+] oscillations in neurones of frog sympathetic ganglia.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Cseresnyés Z; Bustamante AI; Schneider MF
J. Physiol. (Lond.), 1999


Table 2

Effect of a 50% increase or a 50% decrease in the value of each adjusted (top 6 entries) and unadjusted (bottom 6 entries) model parameter on oscillation properties

50% increase 50% decrease


Frequency Amplitude Width Frequency Amplitude Width
kSERCA +/+ + ++ 0/- 0
kRACT * ++/+ + * —/-
KD (CICR) 0/0 + 0/— ++
kRyR,0 ++ −/— 0 ++/+ +
koff,PM −/0 0 +/0 +
α ++/+ + ++ —/—
kon,R * +/0 + * —/0
koff,R 0 —/0 0 ++/0 +
kPM + 0/0 0 +/0 0
kRyR,1 + 0/0 0 0/0 0
kon,PM +/0 0 ++ +/0 0
kPMCA ++ +/0 –/0 +
  • Definition of symbols: 0, no change; + and ++, moderate and large increase; − and —, moderate and large decrease

  • * The fact that the frequency decreases with both a 50% increase and 50% decrease in these parameter values indicates that the starting value is near a local maximum in the dependence of frequency on these parameters


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Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source