50% increase | 50% decrease | |||||
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Frequency | Amplitude | Width | Frequency | Amplitude | Width | |
kSERCA | — | +/+ | + | ++ | 0/- | 0 |
kRACT | –* | ++/+ | + | —* | —/- | — |
KD (CICR) | — | 0/0 | – | + | 0/— | ++ |
kRyR,0 | ++ | −/— | 0 | — | ++/+ | + |
koff,PM | — | −/0 | — | 0 | +/0 | + |
α | — | ++/+ | + | ++ | —/— | — |
kon,R | —* | +/0 | + | —* | —/0 | — |
koff,R | 0 | —/0 | 0 | — | ++/0 | + |
kPM | + | 0/0 | 0 | — | +/0 | 0 |
kRyR,1 | + | 0/0 | 0 | — | 0/0 | 0 |
kon,PM | — | +/0 | 0 | ++ | +/0 | 0 |
kPMCA | ++ | +/0 | – | — | –/0 | + |
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Definition of symbols: 0, no change; + and ++, moderate and large increase; − and —, moderate and large decrease
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↵* The fact that the frequency decreases with both a 50% increase and 50% decrease in these parameter values indicates that the starting value is near a local maximum in the dependence of frequency on these parameters